The skin is the largest organ of the human body, a strategic and irreplaceable covering that acts as a protective barrier against the external environment: it absorbs and blocks radiation, modulates the loss of water, presides over the pigmentation (melanin) and is one of the principal sensory organs because it is rich in nerve endings that receive and transmit external signals.
It is a complex structure made up of 3 different layers: epidermis, dermis and hypodermis.
Starting from the surface:
- Epidermis: the outermost layer, a real barrier in constant change, not vascularized, consisting of 5 layers that correspond to different stages of keratinocytes life cycle. The epidermis hosts melanocytes for the pigmentation, Langerhans cells for the activation of the immune response and Merkel cells associated with the nerve endings to transfer the sensations. The stratum corneum is coated with a special hydro-lipidic film full of water and lipids, sebum, sweat and small molecules named Natural Moisturizing Factor (NMF), which preserves the moisture and elasticity of the skin, at pH 5.5 acid then bactericide.
- Dermis: connective tissue, the support and nourishment for skin and cutaneous structures as hair follicles, nails, sweat and sebaceous glands. It is richly vascularized, it also contains blood and lymph vessels, nerves, skin appendages, inflammatory mediators and immune cells, fibroblasts and Collagen and Elastin, protein fibers providing respectively mechanical strength and elasticity to return to its original size after a traction. These fibers are immersed in the fundamental or amorphous substance mainly made by glycosaminoglycans, including Hyaluronic Acid able to bind water molecules giving hydration and firmness to the tissues.
- Hypodermis: subcutaneous adipose tissue.
By the passage of time and exposure to environmental stress and emotional skin deteriorates, becomes increasingly thin and fragile, loses elasticity and cell regeneration becomes slower.
To keep your skin healthy and beautiful, hygiene and daily care are essential. Targeted and gentle they help to preserve the natural protective function while maintaining the hydro-lipidic mantle and the pH level against external agents.
Kleraderm Pharma offers a dermatological range of products with action – prevention effect. From cleansing to face and body treatments for a skin that immediately appears smoother, brighter and regenerated.